Dexter, Avatar Dexter, Avatar

It was a record-setting night at the 67th Golden Globe Awards as Mad Men became the first drama series to three-peat and Meryl Streep picked up her record seventh Globe trophy to become the winningest performer in the history of the ceremony.

James Cameron's epic blockbuster Avatar was named best drama picture, and Cameron earned the best director prize. The Hangover won best comedy picture and is the first film since Babe, 14 years ago, to win the category without any other nominations. Dexter's Michael C. Hall, who announced recently he's battling cancer, received some welcome news: He won in the best dramatic TV actor category and his co-star, John Lithgow, won for supporting dramatic TV actor.

Winning for Julie & Julia in the film comedy actress category, Streep beat three other actresses and herself in It's Complicated. Her It's Complicated co-star, Alec Baldwin, earned his third trophy for TV comedy actor for 30 Rock.

Check out all the Golden Globes red carpet hits and misses

"It means a great deal to have the admiration of the people in my film community. I don't live in the glare of the spotlight. I come from my little outside life and I come into this room with every person I've ever worked with," Streep said. "It's like a little homecoming."

Streep's co-winner at the Critic's Choice Awards, Sandra Bullock, won her own Golden Globe for film drama actress for The Blind Side, while Jeff Bridges (Crazy Heart) was named film drama actor and Robert Downey Jr. (Sherlock Holmes) won his third Golden Globe for film comedy actor.

On the TV side, newcomer Glee, which led all TV nominees with four nominations, won the biggest one: TV comedy series.

Despite its three-peat in the best dramatic series category, Mad Men's leads, January Jones and Jon Hamm, came up short. Jones lost to Julianna Margulies (The Good Wife) for TV drama actress and 2008 TV drama actor Hamm was bested by Dexter's Michael C. Hall.

Hall wore a black head covering as he won his first Globe in four nominations. "I think a matter of personal health is personal ... Because the award shows were imminent, I thought I had to make a statement," Hall said backstage, explaining why he chose to announce his cancer diagnosis."

Hall said of his headwear: "It's nice to have a justifiable excuse for accessorizing."

See all the Golden Globes red carpet arrivals

Mo'Nique won the first award of the night — best supporting actress in a film — for her turn as an abusive mother in Precious.

"Thank you God for this amazing ride that you're allowing me to go on," she said in her speech. "I celebrate this award with everyone who's ever been touched," she added, referring to the film's exploration of sexual abuse. "It's now time to tell."

Toni Collette won for TV comedy actress in United States of Tara, while Chloe Sevigny (Big Love) won TV supporting actress and Christoph Waltz was named film supporting actor for his villainous turn in Inglourious Basterds.

Other winners included Up for animated feature, Drew Barrymore (Grey Gardens) for TV movie/miniseries actress and Kevin Bacon (Taking Chance) for TV movie/miniseries actor. Bacon and his wife, Kyra Sedgwick, now have his-and-hers Golden Globes. Sedgwick won for The Closer four years ago.

Martin Scorsese received the Cecil B. DeMille Award.

Watch the Golden Globes Fashion Wrap with Carrie Ann Inaba on Monday, Jan. 18 at 8/7c on TV Guide Network.

Check out the full list of winners below and visit our Golden Globes section for complete coverage:

Best Drama:

Mad Men

Best Comedy/Musical:

Best Actor-Drama:
Michael C. Hall, Dexter

Best Actress-Drama:
Julianna Margulies, The Good Wife

Best Actor-Comedy/Musical:
Alec Baldwin, 30 Rock

Best Actress-Comedy/Musical:

Toni Collette, United States of Tara

Best Actor-TV Movie/Miniseries:
Kevin Bacon, Taking Chance

Best Actress-TV Movie/Miniseries:
Drew Barrymore, Grey Gardens

Best Supporting Actor:
John Lithgow, Dexter

Best Supporting Actress:

Chloe Sevigny, Big Love

Best Drama:

Best Comedy/Musical:
The Hangover

Best Director:
James Cameron, Avatar

Best Lead Actor-Drama:
Jeff Bridges, Crazy Heart

Best Lead Actress-Drama:
Sandra Bullock, The Blind Side

Best Lead Actor-Comedy/Musical: Robert Downey Jr., Sherlock Holmes Best Lead Actress-Comedy/Musical: Meryl Streep, Julie & Julia Best Supporting Actor: Christoph Waltz, Inglourious Basterds Best Supporting Actress: Mo'Nique, Precious Best Screenplay: Jason Reitman and Sheldon Turner, Up in the Air Best Original Score: Michael Giacchino, UpBest Original Song: "The Weary Kind (Theme from Crazy Heart)," Crazy Heart Best Animated Feature:
Best Foreign Language Film: The White Ribbon, Germany