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The only connection between this picture and its predecessors, THE FLY and THE RETURN OF THE FLY, is the employment of a teleportation device to transport humans from one place to another. While scientist Donlevy spends all his free time experimenting with the machine, his son Baker weds the loony Gray. She gets even goofier when she discovers a closet full of mutants--all failed experiments from Donlevy's work. The police are informed, and, when they arrive, Donlevy uses his device to make his getaway. While transmitting, the machine goes on the fritz, leaving the scientist a molecular mess.