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Jesse James (John Lupton) and gang member Hank (Cal Bolder) escape a posse and seek the help of a young Mexican woman, Juanita (Estelita). She takes them to some ruins owned by Maria Frankenstein (Narda Onyx), the granddaughter of Baron Frankenstein (the title wrongly calls her his daughter). In the family tradition, Maria transplants the brain from her grandfather's monster into the brawny Hank, turning him into a mindless killer outlaw named Igor. This gets the local marshal riled up, and he reckons he should put a stop to this nonsense. The companion piece to the equally ludicrous horror-western BILLY THE KID VS. DRACULA (1965), this was veteran hack director William Beaudine's swan song, after having helmed more than 150 feature films of a similar nature.