Laura San Giacomo, Jane Kaczmarek and Annabella Sciorra star in a fact-based story about close sisters who form an even stronger bond when one of them (San Giacomo) is diagnosed with ALS. Marilyn Estess: Jane Alexander. Jack: Vincent Spano. Nina: Marisa Tomei. Dr. Feldman: Rob Morrow. Nurse Vandemal: Camryn Manheim.