Sheryl Crow, Melissa Etheridge, Amy Grant, Cyndi Lauper, Wynonna, Heart and Destiny's Child perform in a 2000 benefit concert from the Wiltern Theater in Los Angeles to raise awareness and funding for the fight against breast cancer. Other appearances include Ellen DeGeneres, Jenna Elfman, Sarah Michelle Gellar, Holly Hunter, Allison Janney, Nancy McKeon and Gina St. John.