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Scott Foley and Patrick Wilson
The actors are brothers-in-law through marriage. Foley has been married to Polish actress Marika Dominczyk since 2007 and Wilson has been married to her fellow thespian sister Dagmara Dominczyk since 2005. Though the actors have never shared the screen together, Wilson will star in Foley's 2014 directorial debut Let's Kill Ward's Wife, which Foley also wrote.
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Jason Sudeikis and George Wendt
Humor definitely runs in the family. Sudeikis is the nephew of the Cheers star (his mother and Wendt are siblings). "George is a funny guy and my dad's really funny," Sudeikis said. "And I was very lucky that, as a kid, I was drawn to a lot of funny friends. Even now, I still hang out with a lot of them, and they all have very, very different senses of humor."
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Macaulay Culkin, Kieran Culkin and Rory Culkin, and Bonnie Bedelia
The Parenthood actress doesn't only have a big family on screen. Her nephews include Macaulay, Kieran and Rory Culkin, the sons of her actor-brother Kit Culkin.
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Julia Louis-Dreyfus and Patrick Fischler
The Lost and Mad Men actor is married to Louis-Dreyfus' half-sister, actress Lauren Bowles, who was his college sweetheart. "The first thing I remember about Patrick is how he was looking out for my sister long before they started dating," JLD said in 2009. Fischler guest-starred on his sis-in-law's series Veep In 2012.
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George Clooney and Tessa Ferrer
ER and Grey's Anatomy have more in common than just being hospital dramas! The actress' father, Gabriel, is the cousin of the erstwhile Dr. Doug Ross.
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Brooke Shields and Glenn Close
The actresses are second cousins once removed. Shields' great-grandmother and Close's maternal grandfather were siblings.
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Al Roker and Lenny Kravitz
The Today weatherman and the rocker are cousins through their grandfathers. "We both have Roker," Kravitz said on Today in 2011. "My mother was Roxie Roker, my grandfather, Albert Roker from the Bahamas."
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Lily Allen and Alfie Allen
Long before Alfie became Theon Greyjoy on Game of Thrones, he was immortalized in his older sister's song, "Alfie," in which she reprimands him for "wasting his life away." Guess he proved her wrong.
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Regis Philbin and Mike Schur
The Office and Parks and Recreation producer is married to Philbin's daughter, Jennifer "J.J." Philbin, who wrote on The O.C.
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Emily Blunt and Stanley Tucci
The Devil Wears Prada co-stars became in-laws in 2012 when the actor married her sister Felicity after Blunt set them up. This also makes Tucci and John Krasinski brothers-in-law!
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Henry Winkler and Richard Belzer
Yup, The Fonz and Munch are related — cousins to be exact. Belzer appeared in Winkler's 1982 film Night Shift and Winkler guest-starred in an episode of Law & Order: SVU in 2002.
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Robert and Chris Pine
The Star Trek star wasn't a pretty face who came out of nowhere. His father Robert starred on CHiPS as Sgt. Getraer. Not only that, but Papa Pine also guest-starred on Star Trek: Voyager and Star Trek: Enterprise.
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Clark Gregg and Joel Grey
We might not know what Coulson is yet on Marvel's Agents of S.H.I.E.L.D., but we do know that Gregg is the son-in-law of the Cabaret Oscar winner. He has been married to Grey's daughter Jennifer since 2001.
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Martha Plimpton and Michael Bowen
The Raising Hope star calls the Breaking Bad villain uncle Jack. Both are members of the Carradine acting dynasty: Bowen is the half-brother of Plimpton's father Keith Carradine.
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Lorraine Bracco and Aidan Quinn
The actors are in-laws through Quinn's marriage to Bracco's sister Elizabeth. Though Quinn and Bracco have never worked together, Elizabeth has appeared on her sister's show The Sopranos as Vito's wife.