"Christian Slater would be a cool choice." — basic315140

"Balthazar Getty from Brothers and Sisters... He looks and sounds just like Charlie." — BetsyofTexas

"How about Michael J. Fox? It would be a great way to end the show, as Sheen replaced Fox on Spin City. Fox can still act (he was unctuous as hell on The Good Wife) and there would be an immediate positive buzz." — jdavis3

"How about getting Mathew Broderick as Jon [Cryer] is confused for him in real life. That might be interesting casting." — DarylZer0

"Emilio Estevez would make it an interesting show to watch for a number of reasons..." — Cyclop

"Only ONE man can replace Charlie in this VITAL role... MARTIN SHEEN!" — BlueSeed1

"Ted [McGinley], duh. That's his job... replacing departed sitcom characters. He's the patron saint of shark-jumping" — lwingo

"Rob Lowe is hilarious and would make a good replacement but only if they change the basic character: he cannot be another Charlie. That character was wired to self destruct and nobody wants him back after this mess. They should create a new character around Lowe's own comedy. I never watched the show but I would watch it if Lowe were the new lead." — lily1

"If they want to keep a similar dynamic, bring in Will Arnett who's hysterical and plays a great smug, egotistical, party-er type who'd be irritated as all get out by someone like Cryer's character." — Amore22

"Tom Cavanaugh would be an amazing choice. He's already proven he's got comedy chops, both verbal and physical. He'a certainly got a look that I think would attract attention to the show and sometimes a 'dark horse" choice is better than that usual list of suspects!" — SetScotlandFree

"I think Henry Wrinkler (The Fonz) should move in as Alan's ex-father-in-law, so he can be close to his grandson. With the writers and the wits of both [Cryer] and Henry, this show would again be on top." — jerryd369

"Gary Busey could easily replace Charlie Sheen." — Chappel

"Give Jason Bateman a job. Hire anyone good and morally responsible to play a part. Or else cancel the show for good. It's not that great." — RebeccaMcKenna

"My first thought was Robert Downey Jr., but he is too big of a star." — trisha57

"Both Rob Lowe and John Stamos would be good for the part, but I think John Stamos would be a better choice." — LupeAlvarez

"I would love to see James Spader in anything. He was great with Denny Crane [on Boston Legal], but wouldn't mind Robert Downey Jr. They're both terrific actors and better than Sheen. I hope the show continues." — trombone

"Who should replace Charlie Sheen? A TROLL. — sauly001