Airs: Wednesday, April 18 at 9/8c
The Season 13 finale will be a two-hour affair that sees the team heading to New Mexico to tackle an unsub that has a thing for drilling holes in his victims' heads. However, the second hour is when the real action kicks off when Reid (Matthew Gray Gubler) is pulled off sabbatical after he's emailed the alleged location of a former FBI agent's body. What Reid finds instead kicks off a high-stakes search for the truth and ends with a jaw-dropping cliffhanger that leaves multiple agents' lives in danger.

Airs: Thursday, April 19 at 10/9c
As to be expected, things will be coming to a head in the Scandal series finale. Mellie (Bellamy Young) will be fighting to clear her name and keep her post as commander in chief. Meanwhile, Olivia (Kerry Washington) is slowly working her way toward redemption, which is proving to be more complicated than anticipated. As their stories come to a close, no one will walk away from this unscathed. "Everybody pays the price in one way or another for what they've done," Darby Stanchfield previously told TV Guide.

Airs: Thursday, May 10 at 8/7c
Season 11 will end with Sheldon (Jim Parsons) and Amy's (Mayim Bialik) wedding, at which we'll finally meet Sheldon's brother George (Jerry O'Connell) as an adult. Everyone wants the wedding to be special day, but Murphy's Law always prevails with this gang. "There's not a lot of comedy to mine in things going as planned," says Johnny Galecki. Still, he thinks they might pull together and deliver a dream wedding.

CBS has also announced a number of guest stars for the finale, including Kathy Bates and Mark Hamill. Elsewhere, Laurie Metcalf is back as Sheldon's mother, while Courtney Henggeler, who plays Sheldon's twin sister Missy, will make her first appearance since Season 1. John Ross Bowie and Brian Posehn are also back the gang's CalTech coworkers; Wil Wheaton will be return to play the fictional version of himself that is Sheldon's frenemy; and Lauren Lapkus, who will make her Big Bang debut in the April 19 episode, will appear as comic book store employee Denise.

Airs: Tuesday, May 15 at 9/8c
After seven seasons, New Girl comes to a close with a special one-hour season finale wherein the will they/won't they is whether or not Jess (Zooey Deschanel) and Nick (Jake Johnson) will get engaged. What more could you ask for, right? Of course, there will be a lot of obstacles standing in the way before the couple can get to that point, including but not limited to: Jess' father's blessing expiring due to Nick's chronic procrastination, Jess having a dog adoption crisis at the time Nick has planned to propose and, of course, a squirrel stealing the ring. You know, typical Nick Miller stuff. But the good news is, we have a feeling it'll all work out in the end, if this photo of Deschanel dressed in white and wearing a flower crown is to believed.

Airs: Wednesday, May 16 at 10/9c
From the sounds of it, the season ender of ABC's political thriller will be its biggest yet. When TV Guide caught up with showrunner Keith Eisner to ask what's in store, he dropped three bombs. "In the finale of Designated Survivor, someone will quit, someone will die, and the future of the Kirkman presidency will be decided," Eisner reveals. "[His presidency] will be very much in doubt over the course of the episode, but it will be resolved by the end of the episode." And it's not just a new story that comes in to dominate the narrative. Kirkman's tenuous grasp on the Oval Office will be affected by everything we've seen so far as well as new problems that arise. "Everything that has happened over the course of Kirkman's presidency comes home to roost in the finale," Eisner says. "How that plays out is something that involves Michael J. Fox's character, the president, and the president's staff."

Airs: Thursday, May 17 at 8/7c
Big changes are coming to Grey's Anatomy following the news that both April (Sarah Drew) and Arizona (Jessica Capshaw) are slated to leave Grey Sloan at the end of the season. For April, who has been experiencing a crisis of faith as of late, the news isn't that surprising. But for Arizona, who found a way to reduce maternal mortality rates, her new invention could lead her to bigger and better things outside of Seattle. While details on their departures are being kept under wraps, we do know the last appearance of both women will be in the season finale, titled "All of Me," which was written by executive producer Krista Vernoff and directed by Debbie Allen.

Airs: Thursday, May 17 at 8/7c
As Sam (Jared Padalecki) and Dean (Jensen Ackles) continue the search for Mary (Samantha Smith) and Jack (Alexander Calvert), the latter will finally come face-to-face with his evil father, Lucifer (Mark Pellegrino). The intense meeting will bring up a mixture of emotions, especially when Jack notices some startling similarities between father and son. "In Lucifer, he may see parts of himself that he does not necessarily like," executive producer Andrew Dabb tells TV Guide.

Plus, after 13 seasons, Jensen Ackles will finally step into the shoes of someone other than Dean Winchester, and according to executive producer Robert Singer, fans should prepare themselves, because this one is going to be a season ender. "It's a bold choice for us, but I think it's really going to pay off," adds Dabb.

Airs: Friday, May 18 at 8/7c
A number of familiar faces are returning to say goodbye to Once Upon a Time. Original series stars Jennifer Morrison, Ginnifer Goodwin, Josh Dallas, Jared Gilmore and Emilie de Ravin are all slated to return to the fairy-tale series before the final credits roll. However, they're not the only people returning. In fact, one of the most exciting returns is actually that of Sean Maguire, who plays Regina's lost love Robin Hood. According to Lana Parrilla, fans will be very happy by Regina and Robin's long-awaited reunion. "It is all of what you hoped. It's beautiful and it's Outlaw Queen. It's their beautiful dream and their loving relationship," Parrilla tells TV Guide. Guess that means it's time to start getting excited!

Airs: Friday, May 18 at 9/8c
Marvel's Agents of S.H.I.E.L.D.'s season finale could also serve as a series finale, and Jeff Ward says the season-ender is EPIC. "I think it's some of the more epic territory that the show has crossed into in its entirety as a series." Ward says. "I think the fans are going to really think it's something... I will say, I didn't know if they would be able to pull off the series slash season finale vibe, and it kind of potentially serving as both, and I think they've nailed it. They absolutely nailed it. Because if it is the end, it is a satisfying one, but I also think that the fans are going to be clamoring for more. It has a beautiful journey that it goes on, but I think there's more to be said afterwards."

Airs: Tuesday, May 22 at 8/7c
We have some bad news for the fans who've been on pins and needles waiting to find out the identity of the mystery girl who's been popping up in Jitters every now and then on The Flash. TV Guide has learned that the reveal of who Jessica Parker Kennedy is playing will apparently be a season-ending storyline. Looks like you still have time to come up with theories!

Airs: Tuesday May 22, at 8/7c
The health care issues that have framed the first season of the Roseanne revival only intensify as the season of the reboot concludes. Those aches and pains Roseanne (Roseanne Barr) has been complaining about all season? She's been dealing with them in a way that will shock everyone, including her husband Dan (John Goodman), who sets an ultimatum and vows to find a way to solve her underlying issues. But what he thinks he knows isn't the half of it. The question is, will he get her the help she needs before things get worse?

Airs: TBD
The Season 5 finale will scratch that itch that's been in your head all season long. "We are going to answer the big question of who is in this duffle bag, who do these bones belong to, we're going to answer that," creator Jon Bokenkamp tells TV Guide. "It is a very compelling answer, and probably the biggest turn so far in our series." Could the "Red isn't Red" theory actually be true? Hmm... And whoever's bones those are will cause even more tension between Liz and Red (as if they needed any more), as Liz begins to take on more of her father's traits. "We're not only seeing Red versus a formidable FBI agent," Bokenkamp says, "we're seeing Red against a woman who has lost her husband and her family and really feels like she has nothing left to lose. So the push to our season finale is going to be incredibly physical, incredibly fast and full of surprises."

Airs: TBD
This summer we're finally bidding adieu to Klaus Michaelson (Joseph Morgan) and the Original family after five-plus seasons of supernatural drama. The final season of The Originals promises to put "Always and Forever" to the test one last time, while also giving fans all the family feels they've come to know and love over the years. "So few shows get the opportunity to kind of call their own ending and to have a whole year to plan it and to really know that they're coming to the end of the story," creator and executive producer Julie Plec tells TV Guide of the final season. "It's been a luxury and a blessing and a very emotional ride because we've gotten to have a whole year to really decide how we want these characters to close out the whole series... The best thing I can say about this show -- and any kind of legacy I want it to represent -- is truly the power and the absurdity of family."

Airs: Wednesday, May 9 at 10/9c
The showdown between Voight (Jason Beghe) and Woods (Mykelti Williamson) is about to get even uglier; now that Olinksy (Elias Koteas) is caught in the crossfire, it's not just Voight's badge on the line, and all parties involved are determined to fight for survival to the bitter end. "It's a dangerous, tense triangle between three tough, cagey cops," showrunner Rick Eid tells TV Guide. The intense fight, which will be the focus of the remaining episodes of the season, will also see Ruzek (Patrick John Flueger) and Antonio (Jon Seda) step in to help their embattled leader.

Airs: Thursday, May 10 at 9/8c
Could Firehouse 51 lose its beloved leader at the end of the season? Chief Boden (Eamonn Walker) is in the running for commissioner of the fire department alongside Chief Grissom (Gary Cole), and the fierce competition between the two will adversely affect the rest of the crew. "[Boden and Grissom] being considered is going to cause some stress on the firehouse," showrunner Derek Haas tells TV Guide. Plus, Renee's (Sarah Shahi) sudden re-emergence will stir up some trouble for Severide (Taylor Kinney), who just reignited things romantically with Kidd. "She comes back into Severide's life at what could be considered an inopportune time," he teases.