Lori Loughlin and Rob Estes, 90210Where You Know Them From: Loughlin was on Full House and Summerland; Estes was on Melrose Place and Women's Murder Club. Their New Gig: Impossibly hot parents to 90210's new kids.
2 of 14 Tony Barson/WireImage.com
Ian McShane, KingsWhere You Know Him From: His defining role as Al Swearengen on HBO's Deadwood.His New Gig: McShane plays a modern King David, in a world that's sort of like ours, except... not (details are sketchy).
3 of 14 Dan MacMedan/WireImage.com
Shiri Appleby, ERWhere You Know Her From: She starred with a then-unknown Katherine Heigl in Roswell.Her New Gig: Must be something about the lab coats - Appleby plays an intern on the final season of ER.
4 of 14 Monty Brinton/CBS
Jay Mohr, Gary UnmarriedWhere You Know Him From: A couple of years on SNL and, recently, a recurring role on Ghost Whisperer. His New Gig: Unmarried Gary is a divorced dad trying to balance his ex and his new love life.
5 of 14 Michael Lavine/Fox
Joshua Jackson, FringeWhere You Know Him From: Who could forget Pacey from Dawson's Creek His New Gig: He's an investigator of the paranormal in Lost mastermind J.J. Abrams' new Fox sci-fi drama.
6 of 14 Mitchell Haaseth/NBC
Selma Blair and Molly Shannon, Kath KimWhere You Know Them From: You'll recognize Blair from the Hellboy movies; Shannon was SNL's Mary Katherine Gallagher.Their New Gig: A dysfunctional mom and daughter in the U.S. take on an Aussie hit.
7 of 14 Jim Spellman/WireImage.com
James Tupper, Samantha WhoWhere You Know Him From: The felled ABC series Men in Trees. His New Gig: He'll play a philanthropist out to woo Samantha on Who
8 of 14 Cliff Lipson/CBS
Elizabeth Reaser, The Ex ListWhere You Know Her From: She was amnesiac Ava/Rebecca on Grey's Anatomy. Her New Gig: Reaser's Bella has one year to get married - and her true love is someone she already knows.
9 of 14 Frazer Harrison/Getty Images
Gale Harold, Desperate HousewivesWhere You Know Him From: He was the domineering Brian on Queer as Folk. His New Gig: In last season's finale, we met Housewife Susan's apparent new love interest, Harold's Jackson.
10 of 14 Cliff Lipson/CBS
Simon Baker, The MentalistWhere You Know Him From: Movies like The Devil Wears Prada and his starring roles on TV's The Guardian and the short-lived Smith. His New Gig: Baker's Patrick Jane is a psychic-turned-crime-solver.
11 of 14 Marcel Williams/Warner Bros.
Rufus Sewell, Eleventh Hour Where You Know Him From: He played Alexander Hamilton in HBO's John Adams and Heath Ledger's rival in A Knight's Tale. His New Gig: Sewell is Jacob Hood, a scientist who advises the FBI.
12 of 14 Monty Brinton/CBS
Marley Shelton, Eleventh Hour Where You Know Her From: Quentin Tarantino's Grindhouse; Tobey Maguire's love interest in Pleasantville. Her New Gig: Shelton plays bodyguard to Rufus Sewell's scientist.
13 of 14 Adam Larkey/ABC
Michael Imperioli, Life on MarsWhere You Know Him From: Um, a little show called The Sopranos His New Gig: This adaptation has already had cast shakeups, including Imperioli's addition as a circa-1973 police detective.