Modern Family

The classic Gloria Monty soap charting the trials of Port Charles' medical center. Even daytime naysayers tuned in to see the celebrated nuptials of supercouple Luke and Laura, who scored covers of both Time and Newsweek during the same month. Over time, the series flirted with sci-fi, sexy aliens, adventurous location shoots and a late '90s mafia madness. It debuted on April Fools' Day 1963 and spun off the gothic guilty pleasure that was 'Port Charles' (which was canceled in 2003).

Doctors at a Seattle teaching hospital hone their bedside manners on and off the job in this medical drama.

A murder-mystery writer and a homicide detective team up to solve unusual crimes in New York City, and their professional relationship soon crosses the line into romance.

The classic whodunit about the razor-sharp detective with a rumpled raincoat, a bumbling manner and no apparent first name.

David E. Kelley's spin-off from 'The Practice,' set at a high-priced Boston law firm, plays smartly on the chemistry between James Spader (as wry and wily lawyer Alan Shore) and William Shatner (as flamboyant, eccentric partner Denny Crane). Both won Emmys when they introduced the roles on 'The Practice.' Apart from benefiting from a 'Desperate Housewives' lead-in, 'Boston Legal' got a ratings boost when Candice Bergen came aboard as no-nonsense partner (and Crane's ex-lover) Shirley Schmidt.

12 celebrity relatives move into the same house and try to keep their identity secret.