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24 Episodes 2008 - 2009
Episode 1
Thu, Sep 25, 200860 mins
Meredith and Derek find that "happily ever after" isn't as easy as they hoped, Cristina finds interest in a military doctor, and the Chief is surprised to hear that Seattle Grace is no longer ranked as a top-tier teaching hospital.

Episode 2
Thu, Sep 25, 200860 mins
As a group of best friends deal with the aftermath of their car crash, Dr. Torres takes the lead on a groundbreaking course of treatment for one of the patients. Meanwhile, Major Hunt starts to irritate other attendings with his presence in the hospital.

Episode 3
Thu, Oct 9, 200860 mins
Determined to reverse Seattle Grace's slide into mediocrity, the chief lays down some new rules for interns and residents with which no one's happy. Derek asks Meredith for further changes in her living arrangements. Lexie challenges Cristina's diagnosis for a patient with a persistent headache, and the chief's preoccupation with reputation blinds him to problems with the physical plant.

Episode 4
Thu, Oct 16, 200860 mins
Callie worries over her first real date with Erica. Cristina stumbles upon a neglected area of the hospital.
Episode 5
Thu, Oct 23, 200855 mins
George's first day as a resident includes being on a team of surgeons who is performing six kidney transplants in one day, which helps to distract him in seeing that Lexie has feelings for him. Meanwhile, Callie has problems in taking her relationship to the next level with Erica, and Meredith feels slighted when her name is left out of the medical journal report on her clinical trial with Derek.

Episode 6
Thu, Oct 30, 200860 mins
The new military doctor brings a new training method to the residents and interns for dealing with trauma, while Miranda is presented with the task of treating a ten year old girl with an illness that's considered inoperable by many, including Dr. Hahn. Callie questions her preferences, while Meredith stumbles across an old doll while going through some of her mother's things, Lexi avoids George for not asking for her as an intern, and Alex questions what he and Izzie have between them.

Episode 7
Thu, Nov 6, 200841 mins
The residents compete for the opportunity to be the first one to solo, but Izzie's demons return in the form of a patient of Dr. Hahn's, who finds out the real reason her patient still is waiting for a heart. The interns steal cadavers for practice, then have to fight the residents off to keep them.

Episode 8
Thu, Nov 13, 200843 mins
Meredith's best friend from college shows up on her doorstep and Cristina feels threatened by it. Meredith thinks Sloan is putting the moves on her half-sister and asks Derek to intervene, while the interns practice sutures on each other and Izzie still feels Denny's presence. Hahn is suddenly gone from Seattle Grace and everyone immediately feel at odds over her replacement.

Episode 9
Thu, Nov 20, 200860 mins
The interns ask for help from Cristina and Meredith when their back room "study group" has a set back while Izzie continues to wrestle things in her mind by herself. Patients include a father of a teenager who refuses to sleep because she doesn't feel safe and a hypochondriac whose prognosis is not as bad as she feared, but the proposed cure is worse.

Episode 10
Thu, Dec 4, 200860 mins
The race for a resident's first solo surgery comes down to Cristina, who was disqualified because of the actions of her interns, while at the same time is put under pressure to secure the services of a new head in the cardio department. Patients include a couple of sisters who were in a car accident and a woman whose surgery may, or may not, enable her to talk again.

Episode 11
Thu, Jan 8, 200960 mins
Bailey doesn't see eye-to-eye with the new pediatric surgeon on a case she's been involved in for some time. Derek doesn't see eye-to-eye with a patient who's on death row. Alex doesn't see eye-to-eye with the other man in Izzie's life because he's not real, and Meredith and Cristina don't see eye-to-eye on anything, which means they aren't talking and Cristina looks elsewhere to vent. Callie and Mark DO see eye-to-eye on their own personal problem though, which makes for some interesting times for each.

Episode 12
Thu, Jan 15, 200960 mins
Derek refuses to let a death row inmate die from injuries sustained in a prison riot, Miranda refuses to let a little boy die because he can't get the badly-needed transplant, Denny refuses to let his relationship with Izzie die, Lexie won't let her budding relationship with Mark die, and Derek's visiting mother puts everyone's mother first on priority lists.

Episode 13
Thu, Jan 22, 200960 mins
Derek's death row patient attempts suicide and Meredith looks the other way while everybody scrambles for an organ donor. Lexie keeps stumbling into walls after putting Mark in a compromising position. Denny intensifies his time with Izzie and Cristina doesn't know what to think of her Army doctor with problems.

Episode 14
Thu, Feb 5, 200960 mins
Cristina carries on an intense flirtation with Owen, Derek gets advice from everyone on how to propose, Izzie gets some tests done, and Bailey's promotion may stand in the way of a new career possibility.

Episode 15
Thu, Feb 12, 200955 mins
Owen runs into someone very special from his past. Izzie employs her fellow doctors in a medical game made to help teach the interns. Naomi, Sam and Addison rush Archer to Seattle Grace and meet with Derek and Mark to save his life.

Episode 16
Thu, Feb 19, 200960 mins
A mistake in the clinic mixes Izzie's test results with someone else's and sends her on a mission; a mistake by a general surgeon sends Cristina on a mission of her own; a mistake in the operating room by Derek sends him over the edge and ends up squaring off with Addison over a patient.
Episode 17
Thu, Mar 12, 200960 mins
Derek falls apart after the death of his most recent patient, but Meredith is trying hard not to let him give up; Alex refuses to give up on a patient who had an epileptic seizure, while Izzie refuses to let the interns give up; the Chief has all but given up on everyone in the hospital and begins ranting like a madman.

Episode 18
Thu, Mar 19, 200960 mins
As Derek continues his hiding in the woods, all hands are on deck in an effort to get him back. Izzie insists that Cristina keep her secret about her cancer, while snickers abound about Lexi's relationship with Mark, who undertakes the task of performing a facial transplant.

Episode 19
Thu, Mar 26, 200960 mins
Derek returns to operate on Izzie, whose friends use their duties as residents to avoid her, especially George who feels betrayed because Izzie never told him about what was going on. Alex assists Mark on a case where an elderly lady's family does nothing but hover around waiting for her to die and Meredith turns down Derek's proposal because she feels it's all for the wrong reasons.

Episode 20
Thu, Apr 23, 200960 mins
Izzie bites off more than she can chew on her first day of chemotherapy, Mark and Derek are forced to work on the same patient, Meredith's plans for a simple wedding take a turn, and Karev finds himself split between worry over Izzie and excelling as a resident.

Episode 21
Thu, Apr 30, 200960 mins
Izzie's mother comes to town, a little girl shoots her father triggering a conflict between Meredith and the chief, Thatcher reappears, and Callie gets her first taste of life without her trust fund.
Episode 22
Thu, May 7, 200960 mins
A car crash involving students going to their college graduation takes its toll on the residents in the ER, Derek's wedding gift is uniquely suited for Meredith - even if the oversight is not. Meanwhile, Denny's return has Derek and Bailey searching for the cause, and the results will change the outcome of the day.

Episode 23
Thu, May 14, 200955 mins
Izzie is torn over whether to have Derek's proposed brain surgery. A soldier on medical leave asks for a radical operation so he can return to active duty. The Chief tries to lure Bailey back to general surgery with a new toy, and Mark shifts into high gear with major life changes.
Episode 24
Thu, May 14, 200960 mins
Izzie's memory problems panic Alex, the team takes care of a John Doe who was hit by a bus, Bailey rethinks her pediatrics fellowship, and the hospital endures losses.
