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25 Episodes 2006 - 2007
Episode 1
Thu, Sep 21, 200660 mins
When Izzie has a mental collapse after Denny's death, Izzie and Cristina turn to Meredith to try and make it better for her. Callie tries to cope with George not returning the three word sentiment she said to him. Meanwhile, back at the hospital, Alex and Addison deal with a baby left in a garbage can at a local high school, Richard receives an ultimatum from his wife, and Derek and George are quarantined in the locker room due to a patient suspected of having the plague.

Episode 2
Thu, Sep 28, 200660 mins
Patients include a teenage boy with a tree run through him, a man with a tumor on his brain that forces him to be honest, and a patient who goes all out on living before her surgery as the interns begin to go all out on Bailey to ask Izzie to come back to Seattle Grace; Dr. Burke's mother goes all out on breaking Cristina's will; Addison goes all out with the bottle because she found some interesting pocket fanfare in her husband's tuxedo after the prom; and Callie goes all out to make George jealous.
Episode 3
Thu, Oct 5, 200660 mins
Cristina refuses to quit, like she thinks Preston has. Finn and Derek refuse to quit on Meredith, who insists that they date her. Izzie won't quit standing out front of Seattle Grace, waiting for the time she feels is right to see Dr. Webber. Mark won't quit on giving up on Addison, who now realizes her marriage to Derek is over. And Alex wishes she would quit picking him as her intern in the OB-GYN department.

Episode 4
Thu, Oct 12, 200660 mins
Denny's father (Fred Ward) visits Izzie and gives her something that will change everything. Meanwhile, Meredith is diagnosed with appendicitis and while waiting for emergency surgery and high on morphine has a talk with Addison for the first time since Addison found the panties. Mark "McSteamy" Sloan starts working at the hospital and Alex wants to work under him instead of Addison because Mark has a patient with severe facial burns. And while Callie and George break up, Meredith finally picks one man.

Episode 5
Thu, Oct 19, 200660 mins
Guilt causes different actions in everyone, the interns are allowed to attend an M&M meeting, and Derek and Addison finalize things.

Episode 6
Thu, Nov 2, 200660 mins
Derek's sister comes to Seattle for a visit, and seems more into the extended family and gossip surrounding his divorce from Addison than into him. Meanwhile, the interns are not the only ones jealous of Cristina's opportunity to scrub in with Preston on a "Humpty Dumpty" procedure, and Bailey takes it personally when she learns she's been scrubbed, herself. George works with Addison on a very unusual case and Alex envies him.

Episode 7
Thu, Nov 9, 200660 mins
Derek was looking forward to getting away from it all for a few days until his co-workers all go along on a camping trip. Bailey confronts Cristina and another doctor confronts Izzie about her feelings surrounding Denny. Addison and Callie are confronted by a major problem with a pregnant patient.

Episode 8
Thu, Nov 16, 200660 mins
Some of the staff feel the family strings calling as George deals with his father being admitted and it really hits home when a nanny backs her car into one of her charges. Addison steps in when she discovers Sloane using his interns as personal slaves. The walls begin to close in on Cristina and Preston's secret and Meredith vows to be a little more cheery.

Episode 9
Thu, Nov 23, 200660 mins
A traumatic car accident fills the ER. Cristina has a crisis of conscience about her deceptive teamwork with Burke, Izzie pushes the boundaries of her probation, and Callie tries to explain herself to George.

Episode 10
Thu, Nov 30, 200660 mins
Patients include Meredith's half-sister in labor that puts a strain on her personal needs in the family department. George's needs in the family department include a couple of brothers who don't respect him. Richard's needs in the family department include his desire to retire, but Preston's tremor and deception puts the ability to satisfy those needs on hold. Izzie needs to face up to Mark or become his personal slave. And Miranda tries to help Derek get back in the surgeon saddle when he questions his ability, thinking he failed Burke.
Episode 11
Thu, Jan 11, 200760 mins
George's father continues to fight his cancer, while Preston fights Cristina's attempts to find out how he's doing without showing that she really cares. Derek fights with his feelings when he has trouble sleeping with Meredith's snoring, while Meredith fights over her feelings regarding her father, who's visiting his new granddaughter. Izzie fights with Miranda over her multi-million dollar check that Denny left her and has yet to deposit.

Episode 12
Thu, Jan 18, 200760 mins
Addison reveals why she's in the dumps, which explains why Mark is dumping all over her. George is in the dumps about his father's surgery, Derek about Meredith's snoring, and Izzie about the fact that Bailey still won't let her scrub in on any surgeries, even though Izzie pays for one of them. Meanwhile, the cat and mouse game continues between Preston and Christina as they refuse to let the other show how much they really care about each other.

Episode 13
Thu, Jan 25, 200760 mins
When everyone finds out Richard is stepping down they all throw their own name in the hat as his replacement including Mark, who was leaving until he found out about it, too. Bailey gets the idea of a free clinic, as Addison avoids the subject of kissing one of her interns and George deals with a cancer patient after losing his dad for the same reason.
Episode 14
Thu, Feb 1, 200760 mins
A toxic cancer patient immobilizes the hospital, George has an announcement, and Izzie frets that her money was not well spent. Meredith, meanwhile, has new issues with her mother, and Cristina worries that having a personal life could affect her career.

Episode 15
Thu, Feb 8, 200760 mins
Meredith is still reeling from the time spent with her mother, and Derek is getting concerned. Meanwhile, Cristina seems to be delaying her announcement, and everything is put aside when a disaster occurs and each intern is faced with treatment decisions and tasks they are not equipped for.

Episode 16
Thu, Feb 15, 200760 mins
Cristina keeps an eye out around the hospital for Meredith to tell her about her impending nuptials. Izzie fights for the life of her patient, still trapped between two vehicles on the ferry and Derek also searches for Meredith, wondering where she's disappeared to. Alex gets the job of notifying friends and family members about the status of loved ones.
Episode 17
Thu, Feb 22, 200760 mins
An unconscious Meredith interacts with some ghosts from her past while Richard, Burke and Bailey devise an unusual method of reviving her. A despondent Cristina leaves during her shift, and Derek speaks his mind to Meredith's mother.
Episode 18
Thu, Mar 15, 200760 mins
A Korean war veteran with a bullet lodged in his shoulder is admitted. Meanwhile, tensions escalate between Izzie and George, Callie reveals a big secret, Cristina contends with an old flame, and Alex continues to work with the Jane Doe.

Episode 19
Thu, Mar 22, 200760 mins
The board begins to interview for the new chief as positioning takes place between the candidates. Derek is caught, once again, between his job and his girlfriend when Sloan offers Meredith an opportunity he feels she's not ready for. Callie's father comes to town for a visit after she fights with George, who, in turn, goes to Izzie and they get drunk together. Izzie, meanwhile, tries to conceal her secret about that particular night.

Episode 20
Thu, Apr 19, 200760 mins
Meredith feels smothered by her father's wife, while Derek questions the Chief as to why he can't get the man's approval as his replacement. Alex thinks he's found the real identity to his Jane Doe and Izzy gets a request from out of nowhere, leaving her in shock and no George to turn to.

Episode 21
Thu, Apr 26, 200760 mins
The Chairman of Seattle Grace's board of directors is admitted, and the attendings vie for his favor, while the interns study for exams. Izzy and George are reminded of their infidelity, and Burke presses Cristina about wedding plans.
Episode 22
Thu, May 3, 200760 mins
Addison takes temporary leave from Seattle Grace and makes a road trip to Los Angeles in order to visit some old friends from medical school. As Meredith continues to bond with her stepmother, Susan, Cristina reluctantly plans her wedding with the assistance of her mother, Helen, and Burke's mother, Mama Jane. Meanwhile, Derek must perform emergency surgery on Ava/Jane Doe, as Alex continues his unfailing bedside manner with her.

Episode 23
Thu, May 3, 200760 mins
Addison takes temporary leave from Seattle Grace and makes a road trip to Los Angeles in order to visit some old friends from medical school. As Meredith continues to bond with her stepmother, Susan, Cristina reluctantly plans her wedding with the assistance of her mother, Helen, and Burke's mother, Mama Jane. Meanwhile, Derek must perform emergency surgery on Ava/Jane Doe, as Alex continues his unfailing bedside manner with her.
Episode 24
Thu, May 10, 200760 mins
The interns take the biggest test of their careers, their first-year medical exams, as the residents attend to three injured mountain climbers. Meanwhile Callie's suspicions of George and Izzie grow, and Cristina struggles to write her wedding vows.

Episode 25
Thu, May 17, 200760 mins
As the wedding approaches, the bride feels the walls closing in. As the final choice for the new chief approaches, the Attendings feel the walls closing in. Bailey's up for becoming chief resident, as is Callie, who feels like taking her marriage to the next level, possibly only as an effort to hang on to George. The interns get their test results, as Alex finds out Rebecca and her baby are being discharged.
