The series revolves around oh-so-adorable vampire Vampirina who has just moved from Transylvania to Pennsylvania along with her family who are into the bed and breakfast business. At her new school, she has to work hard to strike a chord with her human classmates. Teething problems apart, she gradually finds good friends in next-door neighbour Poppy and there is also Bridget.
A 6-year-old girl communicates with and heals stuffed animals and toys in her backyard clinic. Follow the seven-year-old Dottie "Doc" McStuffins, who wishes to become a doctor like her mother. She practices by fixing her dolls and toys. When she uses her magical stethoscope to effectively heal her toys. Doc McStuffins helps toys recover by giving them check-ups and diagnosing their fictional illnesses. She usually refers to two main encyclopedias "The Big Vet Book" and "The Big Book of Boo Boos".