As Grey's Anatomykicks off its 12th (!) season, it's hard to imagine a world in which Shonda Rhimes wasn't a household name, but that was in fact the case when Grey's Anatomy premiered way back in 2005. Yes, Meredith Grey (Ellen Pompeo) and the rest of the doctors at Grey-Sloan Memorial have been saving lives and swapping romantic partners for a decade now, and have definitely lived through a few lifetimes' worth of tears and heartache along the way (as have viewers).

Grey's reached a turning point at the end of Season 11 by killing off original cast member and fan favorite Derek Shepherd (Patrick Dempsey), leaving Meredith a widow. But the show is rebooting itself in a sense this season, in an attempt to give Meredith a new start and revert back to the original lightness and charm that made it one of the longest-running medical dramas ever. Whether you're a newcomer to the ABC drama or a longtime fan, here's everything you need to know about Grey's Anatomy Season 12:

Grey's Anatomy: Season 12 won't be sunnier for everyone

Grey's Anatomy trailer reveals "everything has changed"

Grey's Anatomy Mega Buzz: What causes "tension" between Callie and Arizona?

Grey's Anatomy: Meredith will experience a "rebirth" following Derek's death

Still mad about that Grey's Anatomy death? Blame Shonda Rhimes

Grey's Anatomy can't replace McDreamy, but they're trying

Grey's Anatomy recap: Will Amelia ever forgive Meredith?

Ellen Pompeo speaks out about Derek's death on Grey's

VIDEO: How well do the stars of Grey's Anatomy know medical jargon?

A definitive ranking of Shondaland Baes

VIDEO: Grey's Anatomy case or Florida news story? We quiz the cast!