The series is set in a middle-class neighbourhood in the heart of the city. There are two different groups of people living there, the ones who have been there for a while, and the ones who have come.
Sydney Fox is a professor and globe-trotting "relic hunter" who looks for ancient artifacts to return to museums and/or the descendants of the original owner. She is aided by her linguistic assistant Nigel and occasionally by her somewhat air-headed secretary Claudia. She often ends up battling rival hunters seeking out artifacts for the money.
Follow the life and crimes of five diverse and treacherous manicurists working at the Nail Artisan of Manatee County salon, where there is a lot more going on than silk wraps and pedicures.