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The bus arrives in Phoenix, AZ to meet newlyweds who want matching bride and groom sugar skulls tattooed on their calves. Tommy gets agitated because the couple doesn't like his sugar skull and makes him draw the design multiple times. Tommy's attitude annoys Thomas and strains their friendship. But after tattooing his sugar skull, Tommy realizes that no matter what tattoo he's doing, at the end of the day, he's always happy tattooing. In better spirits, the crew heads across town to meet Bald John, a former tattoo artist who now owns a Vespa scooter company and wants them to tattoo his company's logo on his back. The logo is a giant gorilla riding a scooter, and it's so big that Thomas and Tommy work together on the tattoo so they can finish it in half the time. Unfortunately, the tattoo is also twice as painful, and Bald John has to drink what seems like a dozen beers to make it through the session. The tattoo turns out great, and by working together, Tommy and Thomas have solidified their friendship. The bus heads back out onto the highway for parts unknown.
Beej's girlfriend, Rhesa, flies in to meet up with the bus and keep Beej company. Thomas fixes a bad tattoo on her lower back while she works out some of her relationship issues with Beej. After the tattoo, Nacho eats a stencil sheet and gets sick. Thomas is desperate to find a vet, and things get worse when the bus overheats and breaks down. Thomas rinses Nacho's mouth out with water to wash out the stencil dye, and it seems to make the pooch feel better. Monica helps get the bus back on the road by suggesting they cool the engine down with water from the bus's water tank. The bus heads to Sedona, AZ and meets Tierza Jacobs, a local psychic. Tierza makes a frightening prediction about trouble at home for Thomas and Monica, but luckily, it turns out to be untrue. Thomas tattoos a dragon on Tierza's hip to complement the art she has collected on her body over the years.
Amy, a new tattoo artist, arrives to join Thomas and his crew. From there, the bus travels to Salt Lake City, UT to meet up with Chris, a former Mormon who wants to get a memorial tattoo to remember his brother who committed suicide. Amy does the tattoo for Chris, but afterwards, Tommy tells her that the tattoo was terrible and that she shouldn't be on the bus. Next, the crew meets up with Marie, a photographer who shoots a doggy calendar every year called Pinups for Pups. Nacho, Thomas' French bulldog, gets in on this year's photo shoot. Tommy tattoos a memorial tattoo on Marie's forearm to remember her dog Sir Avalon who died the year before. Thomas takes the bus to Denver to meet Stacey, a woman who wants to get a butterfly tattoo on her hip to remember her father who recently passed away. Thomas gives Amy a second chance and asks her to do the tattoo. Amy does an amazing job and convinces Thomas and Tommy that she deserves to be on the bus.
Thomas rolls the bus down to San Diego to tattoo a cross on a firefighter who fought the devastating Southern California wildfires of 2007. As the bus travels further south, the crew stops in Yuma to pick up their new, sexy shop helper, Blake. The whole crew takes the night off to tattoo each other, but Chili and Blake decide to get drunk on the bus. Tommy tattoos Chili who starts making lewd and inappropriate advances towards Blake before passing out. The next day, the bus travels to Phoenix, and Thomas calls a crew meeting to confront Chili about his drinking problem. Fearing that Chili may be drinking while he drives, Thomas has no option but to fire him.