In the 2030s Earth has been overrun by the Blue, which are mutated insect-like creatures that kill and harvest humans for food. Most of the surviving human race has moved to Second Earth, a huge spaceship that orbits the planet. Yuji and Marlene must work together to reach Second Earth and fight against the Blue.
Chisato is homeless and on the run from debt collectors, when a wealthy man offers to pay off her debt if she marries him for one month. However, Chisato discovers that there are clauses to the contract after he dies, which includes being the mother of his six sons.
Humans live in the world of Assiah, demons in Gehenna. The two dimensions are not meant to interfere with each other, but demons still possess creatures in Assiah in spite of this. The humans who can fight these demons are known as exorcists. Rin Okumura is a boy who bears the curse of being Satan's illegitimate son. His foster father sacrificed himself to save him from demons. To avenge his foster father's death as well as to prove himself, Rin decides to follow the path of an exorcist and defeat his own father, Satan. To hone his raw skills, Rin enters True Cross Academy to train with other exorcist candidates.
Sara "Pez" Pezzini searches for justice which brings her into contact with the Witchblade. An ancient, intelligent, living weapon so powerful it can battle Earth's darkest evil forces. Week in and week out, Pez employs her skills as a police detective to fight crime. Pez finds she must employ the Witchblade to combat a much greater and frighteningly organized conspiracy of evil that threatens the very soul of humanity.