Pepper Ann

Sue Rose

Kathleen Wilhoite

Pepper Ann, Pepper Ann Pearson, Additional Voices, Didi O'Shaunassy

Danny Cooksey

Milo Kamalani, Milo, Baron Von Gus, Wind

April Winchell

Mom, Lydia Pearson, Sherrie Spleen, Additional Voices, Grandma Lillian, Ms. Abriola Stark, Lydia, Ms. Stark, Grandma, Grandma Pearson, Sherie Spleen, Abriola Stark, Bailiff, Didi's Mom, Ezzy, Gerta Liederhosen, Librarian, Milicent, Milicent the Militant, Millicent the Militant, Mrs. Liederhosen, Operator, Over Protective Woman, Passengers, Soda Can Woman, Too Hip Girl

Clea Lewis

Nicky Little, Nicky

Jeff Bennett

Additional Voices, Dieter Liederhosen, Craig Bean, Dieter Leiderhosen, Pink-Eye Pete, Dieter, Shelf McClain, Grandpa Leo, Ned Diggety, Mitch, Craig, Avery Blake, Dieter Lederhosen, Ernie, Noah, Sir Helpsalot, Bernie, Bob, Bob Lilywise, Bump the Gas Pump, Christmas Tree, Cowboy, Emit Swink, Gelby, Giraffe Head, Gorilla, Hatted Businessman, Larry, Music Store Salesman, Nicky's Dad, Reporter #1, Rowan Keech, Salesman, Short Man, Son of the Soil, TV Announcer, Ticketman, Vittorio

Pamela Adlon

Moose Pearson, Moose, Additional Voices, Cherub, Additonal Voices, Goose O'Shaunassy, Hush, Kid #1, Kid #2, Sean LeSandre, Shouty Kid, Skull, Steve the Cat, Woman Customer #1

Kath Soucie

Cissy Rooney, Additional Voices, Cissy, Nicky's Mom, Tina, Gina, Mean Girl, Mrs. Little, Additional Voices (segment: (Romeo + Juliet)), Debbie, Grammie Pearson, Lycee Girl, Saleslady, Supermodel Mindy, Sweet Lil Girl, Tiny Tim, Woman #2, Young Mother

Jenna von Oÿ

Trinket St. Blaire, Trinket St. Blair, Trinket

Cree Summer

Tessa James, Vanessa James, Additional Voices, Crying Girl, Tessa, Tessa, Vanessa, Vanessa

Susan Tolsky

Aunt Janie, Aunt Janie Diggety, Aunt Lanie, Woman Astronomer

Don Adams

Principal Hickey, Principal Herbert Hickey

Paddi Edwards

Vera Groober-Schwartz, Vera, Vera Groober-Schwartz (segment: (Romeo + Juliet))

Jim Cummings

Mr. Carter, Mr. Roland Carter, Hobo, Nicky's Dad, Additional Voices, Announcer, Computerized Swan, Coordiantor, Mr. Little, Newsstand Owner, Referee, Roland Carter

Don Lake

Mr. Finky, Mr. Sherman Finky, Additional Voices, Butler, DMV Man, Newstand Owner

Tino Insana

Uncle JoJo, Uncle JoJo Diggety, Uncle Jojo, Additional Voices, Earl, Frank

Kathy Najimy

Coach Doogan, Margot LeSandre, Additional Voices, Margot Lesandre, Nelly Lilywise

Maurice LaMarche

Chuck Pearson, Dad, Chuck, Colonel Delaney, Frankie, Gorilla, Jeweler, Menorah, Reggie, Reporter #2, Uncle Harry

Kimmy Robertson

Gwen Mezzrow

Candi Milo

Constance Goldman, Biana, Deeana, Rose

Cam Clarke

Stewart Walldinger, Stuart, Stuart Walldinger

Sue Rose