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After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon over 500-lbs. She has become a hermit after years of shame, and hopes to restart her life so she can better care for her son Zachary.
With the support of his fiance, Kathryn, Robert turns to Dr. Nowzaradan in a final, desperate attempt to save his life. He tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema, and nearly 900-lbs.
Lisa's struggle with her weight began as a child and significantly worsened after witnessing her brother's murder. Now bedridden and unable to care for herself, Lisa must find a way to lose the weight or she will never see her grandchildren grow up.
James "LB" Bonner spent his early life trying to prove himself to his adoptive family, but after losing a leg and battling obesity, LB must take a new path to save his health and his family relationships.