Stand-up comedian Sarah Silverman brings down the house with her lacerating, biting and incisive take on such normally taboo topics as the Holocaust, Sept. 11, AIDS, religion and cancer in a deadly and dead-on performance. Joining her in some off-stage skits are her real-life sister, Laura, and comedians Brian Posehn and Bob Odenkirk. The film also features a few outrageously funny song-and-dance numbers. Directed by Liam Lynch.