This mystery-adventure film features Enola Holmes, the 14-year-old sister of the famous detective Sherlock Holmes and government official Mycroft Holmes. She has been living happily with her mother, Eudoria, who encourages her independent spirit and doesn't let her be bogged down by stifling gendered social norms. However, Eudoria goes missing one day, without a clue. Thus, Enola decides to be a sleuth to find her mother.