Stephanie and Ellie, two American nurses, travel by bicycle through remote northern Argentina and arrive at a small village after a long ride. They settle into a local inn run by Luca and later visit a bar where they meet locals, including Chucho and Michael. The night stretches on with drinking, brief connections, and uneasy attention from strangers. The next morning, their plans fracture when they miss transport and argue over whether to continue together or separately. Ellie chooses to remain behind while Stephanie rides ahead on the road. They agree to meet later at a riverside point outside the village. When Stephanie reaches the meeting location, she finds Ellie's bicycle abandoned and signs of a struggle. Panic sets in immediately as she returns to the village seeking help. Local officer Calvo dismisses her concerns, while Michael offers assistance and reveals he has experienced a similar disappearance in the region, pushing the search into uncertain territory as Stephanie agrees to continue with him.