In the summer of 1999, four graduating students from East Great Falls High in Michigan made a pact to shed inhibitions and lose their virginity. Over a decade later, the story of American Pie (1999) has become a memory. Life has moved on, their glory days as teenagers are long gone, and the old friends realise that time has taken its toll. As they return to their hometown, the clique reminisces about school life. In the meantime, they organise the long-awaited class reunion. During a pivotal weekend, real life will reveal how much things have changed and which bonds have remained unshaken.
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