Was born in Paris, but raised in Washington, DC; her father, Joseph Yeardley Smith, was the first official editor for the Washington Post's obituary desk
Got her big break in 1984 when, as an understudy, she took over Cynthia Nixon's role on Broadway in The Real Thing
Made her TV debut in the 1984 ABC Afterschool Specials production Mom's on Strike
The Simpsons producer Bonnie Pietila wanted Smith for the series after seeing her play a knife-wielding tomboy in the play Livin' on Salvation Street in Los Angeles
Originally read for the role of Bart Simpson, with co-star Nancy Cartwright reading the part of Lisa, who eventually became Smith's character
In 2004, performed a one-woman show titled More, in which she candidly discussed her lonely childhood, plastic surgeries and decades of battling bulimia
Published a children's book titled I, Loreli, in 2009