- Is the sixth of 11 siblings.
- Began acting in school plays and at home with his siblings while growing up.
- Was an ensemble member of Chicago's Body Politic Theatre in the early 1980s and appeared in stage productions that included Translations, The Playboy of the Western World and Falstaff & Hal.
- Performed in productions of What the Butler Saw, Candida and The Mystery Cycle at the Court Theatre in Chicago.
- Made a transition from on-stage roles to television after moving to Los Angeles in the early 1990s.
- Was announcer and head writer for the NPR show The Flea Market.
- Originated the role of Dixon McDaniels in the Victory Gardens Theater's production of Cynical Weathers in 2007.
- Honored with DePaul University's Award for Excellence in the Arts in 2011.
- Ben Amandes — Son
- Eileen — Sister
- Grace — Sister
- Meg — Daughter
- Jamie O'Reilly — Ex-wife
- Gerry Amandes — Brother
- Louise — Sister
- Nancy Everhard — Wife
- Nia — Daughter
- Mary — Sister
- Peggy — Sister
- John Amandes — Brother
- Lorraine — Sister
- Vince Amandes — Brother
- Paul Amandes — Brother
- DePaul University, Goodman School of Drama, Chicago, Illinois, United States (1981)
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