- Is the granddaughter of Helenka Adamowska Pantaleoni, a Broadway and silent-film actress who also helped found UNICEF.
- Was cast in the Charlie's Angels remake Angels '88 after attending the audition on a dare, but the series never got off the ground.
- Made her big-screen debut with a small role in the 1991 crime comedy Switch.
- Won the Saturn Award for Best Actress for her work in 2001 dramedy The Family Man.
- Is an avid golfer.
- Is a Goodwill Ambassador for UNICEF.
- Tim Daly — Significant Other
- Helenka Adamowska Pantaleoni — Grandmother
- Kyd Miller Duchovny — Son
- Neil Tardio Jr. — Ex-husband
- West Duchovny — Daughter
- David Duchovny — Ex-husband
- Anthony Pantaleoni — Father
- Emily Pantaleoni — Mother
- Tom Pantaleoni — Brother
- Attended Sarah Lawrence College, Bronxville, New York, United States
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