- Appeared in commercials for McDonald's and Friendly's restaurants, and SeaWorld.
- The SeaWorld commercial was spoofed on The Tonight Show With Jay Leno to make it appear as if Sean and his onscreen little brother were actually looking at Osama bin Laden in a large fish tank.
- Was cast as the 11-year-old Adam in the ABC sitcom The Goldbergs, which is based on the life of series creator, actor-comedian Adam Goldberg.
- Auditioned for his role on The Goldbergs on a Wednesday, received a callback on Thursday and began shooting the pilot on Friday.
- Has a voiceover role in the Cartoon Network's animated series Clarence.
- Luke Giambrone — Brother
- Vonda Giambrone — Mother
- David Giambrone — Father
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