Attended a Catholic school in Texas for two years in her early teens before being expelled, then lived with her aunt until she was 17.
Quit Universidad Iberoamericana to pursue her dream of becoming an actor, an ambition she had harbored since she was a young child watching Sunday matinees with her father.
Was a major soap star in her native Mexico, but left at the height of her popularity and moved to Los Angeles.
Awards received in Mexico include a TV Novela Award for Best Newcomer for Nuevo Amancer (1989), a Hispanic Imagen Award for Best Actress for Frida (2003), and an Imagen Foundation's Creative Achievement Award (2003).
In 2004, became spokeswoman for Avon's makeup and fragrance lines.
2003, BAFTA Film Awards — Best Actress in a Leading Role: Nominee
2003, Golden Globe — Best Performance by an Actress in a Motion Picture - Drama: Nominee
2007, Emmy — Outstanding Comedy Series: Nominee
2012, Goya Awards — Best Leading Actress: Nominee
2018, Independent Spirit Awards — Best Female Lead: Nominee
2002, Oscar — Best Performance by an Actress in a Leading Role: Nominee
2002, Screen Actors Guild Awards — Outstanding Performance by a Female Actor in a Leading Role: Nominee
2003, Critics' Choice Awards — Best Actress: Nominee
2002, Critics' Choice Awards — Best Actress in a Picture Made for Television: Nominee
2007, Emmy — Outstanding Guest Actress in a Comedy Series: Nominee
Richard Anthony Crenna — Ex-fiancé
Mathlide Pinault — Stepdaughter
Francois-Henri Pinault — Husband
Edward Norton — Ex-significant Other
Edward Atterton — Ex-significant Other
Josh Lucas — Ex-significant Other
Sami Hayek Dominguez — Father
Sami Hayek — Brother
Francois Pinault — Stepson
Diana Hayek — Mother
Valentina Paloma Pinault — Daughter
Attended Universidad Iberoamericana, Mexico City, Mexico; Stella Adler Conservatory, Los Angeles, California, United States