- Was convinced by her sisters to start taking acting classes at the age of 8, joining the Australian Theatre for Young People, which boasts Nicole Kidman and Toni Collette among its alumni.
- Received her first film role at the age of 13, in the Australian comedy Dallas Doll (1994), starring Sandra Bernhard.
- Was awarded the Best Actress Award at the 2000 Venice Film Festival for her role in acclaimed Australian drama The Goddess of 1967.
- Made her first international screen appearance in 2002 with a small part as Queen Amidala's handmaiden, Dorme, in George Lucas' Star Wars: Episode II - Attack of the Clones.
- Did her own singing for her role as Jackie Q in 2010's Get Him to the Greek.
- Made People magazine's 2012 Most Beautiful list.
- 2009, Emmy — Outstanding Supporting Actress in a Drama Series: Nominee
- 2008, Golden Globe — Best Performance by an Actress in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television: Nominee
- 2010, Golden Globe — Best Performance by an Actress in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television: Nominee
- 2010, Emmy — Outstanding Supporting Actress in a Drama Series: Nominee
- 2011, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- 2007, Australian Film Institute Awards — International Award for Best Actress: Winner
- 2000, Venice Film Festival — Best Actress: Winner
- 2003, Australian Film Institute Awards — Best Actress in a Leading Role: Nominee
- 2009, Australian Film Institute Awards — International Award for Best Actress: Nominee
- 2014, AACTA Awards — Trailblazer Award: Winner
- 2013, AACTA Awards — Best Lead Actress: Winner
- 2015, Critics' Choice Movie Awards — Best Actress in a Comedy: Nominee
- George Byrne — Brother
- Brendan Cowell — Ex-significant Other
- Alice Byrne — Sister
- Lucy Byrne — Sister
- Rocco Robin Cannavale — Son
- Bobby Cannavale — Significant Other
- Robin Byrne — Father
- Gregor Jordan — Ex-significant Other
- Jane Byrne — Mother
- Attended University of Sydney, Sydney, New South Wales, Australia