- Made his off-Broadway debut in a 1976 production of The Architect and the Emperor of Assyria, followed by his Broadway debut in the dark fable Teibele and Her Demon in 1979.
- Nominated for a 1982 Genie Award for Best Foreign Actor for the prehistoric drama Quest for Fire, his big-screen acting debut.
- Underwent four hours of makeup each day for his role as Vincent in the late-1980s fantasy series Beauty and the Beast.
- Frequently appears in Mexican director Guillermo del Toro's films, including vampire drama Cronos (1993), action-horror flick Blade II (2002) and the Hellboy series.
- Joined the cable series Sons of Anarchy in 2008, playing the lead character's stepfather, a man who, in Perlman's words, was "born to dominate."
- Active in the Young Storytellers Foundation, which promotes literacy and runs in-school programs.
- Has provided voice work for such animated series as
- Afro Samurai, Danny Phantom and Batman: The Animated Series.
- 1989, Emmy — Outstanding Lead Actor in a Drama Series: Nominee
- 1988, Emmy — Outstanding Lead Actor in a Drama Series: Nominee
- 1983, Genie Awards — Best Performance by a Foreign Actor: Nominee
- 1989, Golden Globe — Best Performance by an Actor in a Television Series - Drama: Winner
- Opal Stone — Wife
- Blake Amanda — Daughter
- Dorothy Ford — Mother
- Brandon Avery — Son
- Lehman College, New York, New York, United States (BFA in Theater, 1971); University of Minnesota, Minneapolis, Minnesota, United States (MFA in Theater, 1973)