- Helped the University of Texas win the NCAA title in 1983; in 1993, became the first UT baseball player to have his number (21) retired.
- Posted an MLB-record 20 strikeouts in a game in 1986 and 1996.
- Was ejected from Game 4 of the 1990 World Series for cursing at an umpire.
- In 1992, along with wife Debbie, founded the Roger Clemens Foundation, which supports educational, charitable and religious activities for children.
- Has earned seven Cy Young Awards, becoming the oldest to win one at 42.
- Has four sons with names beginning with "K," the baseball scoring symbol for a strikeout.
- Has appeared on the big screen in Cobb (1994), Kingpin (1996) and Anger Management (2003).
- Was accused by former trainer Brian McNamee of using steroids and HGH following the 2007 publication of the Mitchell Report on baseball's drug problem.
- Was indicted in 2010 on charges of making false statements to Congress in his 2008 testimony regarding his use of performance enhancing drugs, and was subsequently charged with obstruction of Congress among other offenses. His trial began in July of 2011 but was declared a mistrial on the second day because of prosecutorial misconduct.
- Bess Clemens-Booher — Mother
- Bill Clemens — Father
- Woody Booher — Stepfather
- Kory Allen Clemens — Son
- Kacy Austin Clemens — Son
- Kody Alec Clemens — Son
- Koby Aaron Clemens — Son
- Debbie Clemens — Wife
- Randy Clemens — Brother
- Attended San Jacinto College North, Pasadena, Texas, United States; attended University of Texas, Austin, Texas, United States