Got her start performing on her father Jim O'Brien's radio show
He was a popular weatherman and radio personality in Philadelphia during the 1970s and early '80s, until his untimely death in a skydiving accident in 1983
Worked as an apprentice at the Williamstown Theater Festival in Williamstown, MA; landed roles in several regional theater and off-off Broadway productions
Best-known for playing acid-tongued, man-hunting producer Roz Doyle to radio psychologist Frasier Crane on Frasier
Formed Bristol Cities Productions with best friend (and Frasier costar) Jane Leeves and Leeves' sister, Kathryn
Is an advocate for and a member of the National Breast Cancer Coalition
Awards
2003Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
2002Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
2001Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
2000Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
1999Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:winner
1998Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
1997Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
1996Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
1995Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
1994Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated