- Graduated Phi Beta Kappa and summa cum laude from Bowdoin College.
- Began his acting career in theater with New Crime Productions, a company founded by John Cusack.
- Lead singer and guitarist for the band Doris.
- Cast for the role of Preston Burke in Grey's Anatomy, but had to drop out because of a filming conflict.
- Friends with Private Practice co-star Kate Walsh since the early 1990s, when they were both struggling actors.
- Harvey Adelstein — Father
- Doris Adelstein — Mother
- Josephine Elizabeth Weil-Adelstein — Daughter
- Liza Weil — Wife (separated)
- Bowdoin College, Brunswick, Maine, United States (BA in English, 1991)
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