- Expelled from first high school in 10th grade, finished sophomore year at another school; ended up graduating from the New Mexico Military Institute, where he realized his passion for writing.
- Worked briefly as a pool cleaner.
- Met and roomed with friend and collaborator Wes Anderson at the University of Texas at Austin.
- Served as an associate producer for As Good as It Gets, directed by James L. Brooks, who executive produced Wilson's first feature film, Bottle Rocket.
- Frequently works with long-time friend Ben Stiller.
- 2005, Critics' Choice Awards — Best Acting Ensemble: Nominee
- 2011, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- 2012, Golden Globe — Best Performance by an Actor in a Motion Picture - Comedy or Musical: Nominee
- 2015, Independent Spirit Awards — Robert Altman Award: Winner
- 2002, Critics' Choice Awards — Best Acting Ensemble: Nominee
- 2002, Writers Guild Awards — Original Screenplay: Nominee
- 2002, BAFTA Film Awards — Best Original Screenplay: Nominee
- 2001, Oscar — Best Writing (Original Screenplay): Nominee
- 2006, People's Choice Awards — Favorite On Screen Match Up: Winner
- 2014, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- Jade Buell — Ex-significant Other
- Robert Ford Wilson — Son
- Caroline Lindqvist — Ex-significant Other
- Kate Hudson — Ex-significant Other
- Finn Lindqvist Wilson — Son
- Andrew Wilson — Brother
- Laura Wilson — Mother
- Luke Wilson — Brother
- Robert Wilson — Father
- Sheryl Crow — Ex-significant Other
- University of Texas, Austin, Texas, United States (BA in English, 1991)