- Named after baseball star Orlando Cepeda by his father, a former Phillies player.
- Once worked as a doorman at a hotel in Charleston, SC.
- Got his start in Hollywood as a writer for A Different World, then went on to write for Roc and The Sinbad Show.
- Appeared in Office Space in 1999 with fellow Mad TV alum David Herman; later that year, he had his first major film role in Liberty Heights.
- Appeared in a series of popular 7 Up soda commercials.
- Hosted a short-lived late-night talk show, The Orlando Jones Show, on FX in 2003.
- Acted in a 2006 production of Fences at the Pasadena Playhouse in Pasadena, CA.
- Cocreated the 2006 animated series The Adventures of Chico and Guapo and provided a voice for one of the show's characters.
- Proposed to his wife in 2008 by putting an antique engagement ring around his pet bulldog's neck.
- Is a vegan, but will cook meat for his friends.
- Jacqueline Staph — Wife
- College of Charleston, Charleston, South Carolina, United States (1990)