- Portrayed Snoopy in a high-school production of You're a Good Man, Charlie Brown.
- Played baseball while at Syracuse University.
- Studied at the London Academy of Music, Dramatic Arts and Sciences.
- Made his big-screen debut as a dock worker in the 1990 film Darkman.
- His breakthrough role was as Buck Compton in Steven Spielberg's Band of Brothers.
- Provided the voice of Jesus for the recording of Truth & Life Dramatized Audio Bible.
- Does not do onscreen sex scenes due to his family and Catholic faith and has walked away from jobs in order to stick to his principles.
- 2008, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Comedy Series: Nominee
- Morgan Patrick McDonough — Son
- Catherine Maggie McDonough — Daughter
- Ruve Robertson — Wife
- London Jane McDonough — Daughter
- Clover Elizabeth McDonough — Daughter
- James Hamilton McDonough — Son
- Syracuse University, Syracuse, New York, United States (1988)