- The daughter of popular Brazilian actor Vera Setta, Baccarin was born in her mother's home country, but raised in New York's Greenwich Village.
- While attending Juilliard, served as Natalie Portman's understudy in a New York Shakespeare Festival production of The Seagull.
- First feature-film role came in 2001 with the indie drama Perfume.
- Made her TV debut as Inara Serra on Joss Whedon's cult sci-fi series Firefly (2002-03); reprised her role in the franchise's 2005 big-screen outing, Serenity.
- Was cast as a transsexual in the unaired pilot of the television series It's Always Sunny in Philadelphia in 2005.
- Returned to series-regular work in 2007 with the role of Nurse Jessica Kivala on TNT medical drama Heartland.
- 2013, Emmy — Outstanding Supporting Actress in a Drama Series: Nominee
- 2012, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- Ben McKenzie — Husband
- Austin Chick — Ex-husband
- Fernando Baccarin — Father
- Julius — Son
- Frances Laiz Setta Schenkkan — Daughter
- Vera Setta — Mother
- Attended The Juilliard School, New York, New York, United States