- Appeared in commercials for Heineken, Foot Locker and Home Depot.
- Had a brief career as a stand-up comedian in Los Angeles.
- Met Seth MacFarlane when MacFarlane and Henry's brother Patrick attended college together.
- Apart from his starring role in Family Guy, has lent his voice to other shows such as Robot Chicken and American Dad.
- 2009, Emmy — Outstanding Comedy Series: Nominee
- 2008, Emmy — Outstanding Animated Program (for programming one hour or more): Nominee
- 2011, Emmy — Outstanding Animated Program: Nominee
- Patrick Henry — Brother
- Washington and Lee University, Lexington, Virginia, United States (1988)