- First lead role, as a ninth grader, was as Hawkeye Pierce in a high-school stage adaptation of M*A*S*H.
- Has acted professionally since the age of 13, when he earned his Actor's Equity card for appearing in a Massachusetts stage production of Romeo and Juliet.
- Turned down hockey and football scholarships to study drama at Boston University's School of Fine Arts.
- Made his TV debut (as a cop) on a 1989 episode of Miami Vice.
- Played "Curly" Howard in the 2000 TV-biopic The Three Stooges.
- Real-life daughter Autumn played his character Vic's daughter, Cassidy, on The Shield.
- 2002, Screen Actors Guild Awards — Outstanding Performance by a Male Actor in a Drama Series: Nominee
- 2003, Emmy — Outstanding Lead Actor in a Drama Series: Nominee
- 2005, Golden Globe — Best Performance by an Actor in a Television Series - Drama: Nominee
- 2002, Emmy — Outstanding Lead Actor in a Drama Series: Winner
- 2003, Golden Globe — Best Performance by an Actor in a Television Series - Drama: Winner
- 2004, Golden Globe — Best Performance by an Actor in a Television Series - Drama: Nominee
- Michelle Epstein — Wife
- Autumn Chiklis — Daughter
- Odessa Rose Chiklis — Daughter
- Charlie Chiklis — Father
- Katherine Chiklis — Mother
- Peter Chilkis — Brother
- Boston University, Boston, Massachusetts, United States (BFA, 1986)
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