- Starred in his first commercial at 8 years old for Canadian fast-food chain Tim Hortons.
- Was cast as a regular on I Was a Sixth Grade Alien in 1999.
- Became a popular voice artist on children's series, such as Rolie Polie Olie, The Berenstain Bears and Braceface.
- Made big-screen debut in 2000 with Frequency and Steal This Movie.
- Breakout role was as awkward teen George-Michael Bluth on the critically acclaimed sitcom Arrested Development.
- Created an online comedy series with his friend, Clark Duke, called Clark and Michael.
- Star rose in Hollywood in 2007 when he appeared in Superbad with Jonah Hill and the Oscar-nominated Juno with Ellen Page.
- Co-founded the band The Long Goodbye and was a touring bass player for indie-rock group Mister Heavenly.
- 2004, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Comedy Series: Nominee
- 2009, BAFTA Film Awards — Rising Star Award: Nominee
- 2005, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Comedy Series: Nominee
- 2008, Critics' Choice Awards — Best Acting Ensemble: Nominee
- 2018, Tony — Actor (Featured Role--Play): Nominee
- 2013, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Comedy Series: Nominee
- 2008, Critics' Choice Awards — Best Young Actor: Nominee
- Jordan Cera — Sister
- Molly Cera — Sister
- Aubrey Plaza — Ex-significant Other
- Luigi Cera — Father
- Linda Cera — Mother
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