- Started his comedy career in Boston in the mid-1980s and soon after moved to New York City.
- In 2000, his first one-man show, Jerusalem Syndrome, had an extended off-Broadway run and was released as a book in 2001.
- A few of his comedy album titles include Not Sold Out, Tickets Still Available, and Final Engagement.
- Created, in 2009, the podcast WTF with Marc Maron, which featuring interviews with comedians, old friends, and acquaintances.
- He is often praised for creating a comfortable space on his podcast for comedians to open up about personal issues; notably in his interviews with Robin Williams and Carlos Mencia.
- 2017, Screen Actors Guild Awards — Outstanding Performance by a Male Actor in a Comedy Series: Nominee
- 2017, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Comedy Series: Nominee
- 2017, Critics' Choice Awards — Best Supporting Actor in a Comedy Series: Nominee
- Craig Maron — Brother
- Barry R. Maron — Father
- Toby Maron — Mother
- Mishna Wolff — Ex-wife
- Kimberly Reiss — Ex-wife
- Boston University, College of Arts and Sciences, Boston, Massachusetts, United States (BA in English Literature, 1986)