- Is half-Cuban and half-Venezuelan.
- Moved with her family from Venezuela to Miami at the age of three.
- Plays the piano and guitar in addition to singing, and has released several albums. She also performed numerous songs on the WB/UPN series Roswell in which she starred.
- Nicknamed "Majandra" by her sister, actress Marieh Delfino, who couldn't pronounce her name as a child.
- Performs in a duo with friend Samantha Gibb, daughter of the Bee Gees' Maurice Gibb.
- Danced with the Miami Ballet in the "Nutcracker."
- Acted with her sister, Marieh, in the 2005 film Don't Come Knocking.
- Had her breakout role in 1997 playing Tony Danza's daughter in The Tony Danza Show television series, but found fame on the series Roswell in the late 1990s.
- Mary Hellmund — Mother
- Marieh Delfino — Sister
- Louis Augustus Walton — Son
- David Walton — Husband
- Devon Gummersall — Ex-husband
- Enrique Delfino — Father
- Cecilia Delphine Walton — Daughter
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