- Modeled diapers at the age of 10 months; appeared in a Pepsi TV commercial with NFL Hall of Famer Joe Montana when she was 3.
- Was homeschooled by her mother.
- Appeared regularly in a string of sitcoms (ABC's Full House, CBS's Cosby, Fox's Wanda at Large) and starred with her five siblings Jake, Jazz, Jocqui, Jojo and Jussie on the 1994-95 ABC laugher On Our Own.
- Won a Broadcast Film Critics Award for the 1997 Samuel L. Jackson drama Eve's Bayou, along with NAACP Image Awards for Cosby (1999 and 2000) and the Denzel Washington film drama The Great Debaters (2007).
- Became interested in HIV/AIDS issues when an On Our Own crew member died of AIDS; at age 19, began serving on the board of directors of Artists for a New South Africa, a nonprofit that focuses on HIV.
- 1998, Critics' Choice Awards — Best Child Performance: Winner
- Jake Smollett — Brother
- Jocqui Smollett — Brother
- Hunter Zion Bell — Son
- Jazz Smollett — Sister
- Janet Smollett — Mother
- Joel Smollett — Father
- Josiah Bell — Husband
- JoJo Smollett — Brother
- Jussie Smollett — Brother
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