- At the age of 14, dropped out of high school and legally emancipated herself from her parents in order to further her showbiz career.
- Played a suicidal mental patient in the music video for Melissa Etheridge's "Come to My Window."
- Appeared in a commercial for GAP with the musical duo Daft Punk.
- Lead singer of the rock band Juliette and the Licks.
- 1992, Golden Globe — Best Performance by an Actress in a Supporting Role in a Motion Picture: Nominee
- 1991, Oscar — Best Performance by an Actress in a Supporting Role: Nominee
- 2003, Emmy — Outstanding Supporting Actress in a Miniseries or a Movie: Nominee
- 2013, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- 2003, Independent Spirit Awards — Best Supporting Female: Nominee
- Brandy Lewis — Sister
- Hannah Lewis — Half Sister
- Dierdre Lewis — Sister
- Geoffrey Lewis — Father
- Lightfield Lewis — Brother
- Glenis Batley — Mother
- Paula Hochhalter — Stepmother
- Stephen Berra — Ex-husband
- Matthew Lewis — Half Brother
- Miles Lewis — Half Brother
- Brad Pitt — Ex-significant Other
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