- Served as her high school's class president and valedictorian.
- Co-hosted a free comedy show in Williamsburg for five years with Gabe Liedman and Max Silvestri.
- Was fired from Saturday Night Live after only one season after using an expletive on the air.
- Created a stop-motion short (with her then-husband) called Marcel the Shell with Shoes On in which she provides the voice for the title character.
- Won the Grand Jury Prize at the 2011 New York International Children's Film Festival for Marcel the Shell.
- 2015, Critics' Choice Movie Awards — Best Actress in a Comedy: Winner
- 2015, Independent Spirit Awards — Best Female Lead: Nominee
- Dean Fleischer-Camp — Husband (separated)
- Nancy — Mother
- Stacey — Sister
- Ron Slate — Father
- Chris Evans — Ex-significant Other
- Abigail — Sister
- Columbia University, New York, New York, United States (BA in English and Comparative Literature, 2004)
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