Founded what would become Chicago's Steppenwolf Theatre Company in 1974 with his high-school friends Gary Sinise and Terry Kinney, and served as its artistic director in the 1980s
Met first wife, Laurie Metcalf, when both were theater students at Illinois State University
Made movie debut in Remember My Name, a 1978 drama produced by Robert Altman; appeared in The Wedding (directed by Altman) later that year
Has appeared on some 40 TV series, including Columbo, Family Ties, thirtysomething, L
A
Law, Frasier, NYPD Blue, ER, The West Wing, Lost, Prison Break, Cold Case, C
S
I: Crime Scene Investigation and CSI: New York
Was a regular on CBS's Nash Bridges (1996-2001) A semiregular on Grey's Anatomy (he plays Meredith Grey's father, Thatcher), he's married to series casting director Linda Lowy