In 1990, introduced to future husband Bradley Whitford by Kate Burton, a friend and classmate at the Yale School of Drama, when Whitford and Burton were in a Lincoln Center production of Shakespeare's Measure for Measure
Before daughter Mary Louisa was born in 2002, Malcolm in the Middle writers wrote Kaczmarek's pregnancy into the show, rather than hiding it with props and clothes as they did when she was carrying son George in 1999
In 2002, cofounded (with Whitford) the foundation Clothes Off Our Back, which auctions off celebrity apparel to benefit children's charities
Underwent hip-replacement surgery in April 2004
Competed in the Jeopardy! Million Dollar Celebrity Invitational in 2009, winning $50,000 for Clothes Off Our Back, the charity she cofounded
Awards
2006Emmy-Outstanding Lead Actress in a Comedy Series:nominated
2005Emmy-Outstanding Lead Actress in a Comedy Series:nominated
2004Emmy-Outstanding Lead Actress in a Comedy Series:nominated
2003Emmy-Outstanding Lead Actress in a Comedy Series:nominated
2003Golden Globe-Best Performance by an Actress in a Television Series - Musical or Comedy:nominated
2002Screen Actors Guild Awards-Outstanding Performance by a Female Actor in a Comedy Series:nominated
2002Emmy-Outstanding Lead Actress in a Comedy Series:nominated
2002Golden Globe-Best Performance by an Actress in a Television Series - Musical or Comedy:nominated
2001Emmy-Outstanding Lead Actress in a Comedy Series:nominated
2001Golden Globe-Best Performance by an Actress in a Television Series - Musical or Comedy:nominated
2001American Film Institute-Best Female Actor in a Television Series:nominated
2000Screen Actors Guild Awards-Outstanding Performance by a Female Actor in a Comedy Series:nominated
2000Emmy-Outstanding Lead Actress in a Comedy Series:nominated