- Studied at the American Academy of Dramatic Arts, and the Neighborhood Workshop in New York City.
- Lives by a quote from her grandfather, actor Melvyn Douglas: "All acting, if it's any good, is character acting."
- Favorite actor was Peter Sellers.
- Did stand-up comedy in the 1980s.
- Produced and starred in her own Web series Illeanarama: Supermarket of the Stars.
- Dubbed a number of voices for Martin Scorsese's The Last Temptation of Christ.
- Shared a dressing room with rock singer Deborah Harry of Blondie on the set of New York Stories.
- Once dated Martin Scorsese.
- In his will, her grandfather Melvyn Douglas left her his Best Supporting Oscar for Being There.
- Plays Aerosmith's manager on the pre-ride video for Walt Disney World's Rock 'n Roller Coaster attraction.
- 2002, Emmy — Outstanding Guest Actress in a Drama Series: Nominee
- Stefan Gregor Hesselberg — Brother
- Helen Gahagan — Grandmother
- Jonathan Axelrod — Ex-husband
- Melvyn Douglas — Grandfather
- Erik Hesselberg — Brother
- Gregory Hesselberg — Father
- Joan Georgescu Hesselberg — Mother
- Rosalind Hightower — Grandmother
- Martin Scorsese — Ex-significant Other