- Served as an editor of the "Party Jokes" page of Playboy magazine after graduating from college.
- Worked with both the Canada and Chicago Second City comedy troupes early in his career.
- First TV appearance came in 1976, on the debut season of Canadian sketch-comedy series Second City TV, for which he was also a writer.
- Made his feature directing debut with the hit golf comedy Caddyshack (1980).
- Subsequent hits as a director include the comedies Groundhog Day (1993) and Analyze This (1999).
- Best known as an actor for the role of Dr. Egon Spengler in the 1984 smash Ghostbusters, as well as its 1989 sequel.
- 1994, BAFTA Film Awards — Best Original Screenplay: Winner
- 2015, Writers Guild Awards — The Laurel Award for Screenwriting Achievement: Winner
- 1979, Writers Guild Awards — Original Comedy: Nominee
- Violet Isadora Ramis — Daughter
- Julian Arthur Ramis — Son
- Nathan Ramis — Father
- Anne Plotkin — Ex-wife
- Ruth Ramis — Mother
- Erica Mann — Wife
- Daniel Hayes Ramis — Son
- Washington University in St. Louis, St. Louis, Missouri, United States (BA, 1966)