Formed a Pittsburgh production company called Latent Image, which created industrial films and TV commercials, in the early 1960s
Made his feature-film directorial debut in 1968 with the zombie-horror classic Night of the Living Dead, which spawned several sequels and was eventually inducted into the National Film Registry of the Library of Congress
Met his second wife, Christine Forrest, while he was working on the 1972 horror-drama Season of the Witch, which was produced by his first wife, Nancy Romero
Made a cameo appearance in 1991's The Silence of the Lambs
Received the New York City Horror Film Festival's Lifetime Achievement Award in 2002 and the CineVegas International Film Festival's Vanguard Director Award in 2005